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. 2014 Jun 9;9(6):e98762. doi: 10.1371/journal.pone.0098762

Figure 12. Instantaneous migration speed for cells undergoing an entire cell cycle.

Figure 12

(A–C) Temporal change of instantaneous migration speed along cell cycle progression for MCF-10A, MCF-7, and MDA-MB-231 cells. The cell cycle was scaled to 0–1 to facilitate comparison among different cells within the same cell-line. Values of instantaneous migration speed for each cell examined (blue curves) were lined up with the scaled cell cycle and the mean value of all cells examined was shown by the red curve in each figure. (D) Boxplot of median instantaneous migration speed. MDA-MB-231 cells have highest median value, whereas MCF-10A and MCF-7 cells have comparable migration speed. The Wilcoxon rank rum test showed that there is statistically significant difference in distribution shift of median instantaneous migration speed between MCF-10A and MDA-MB-231, and between MDA-MB-231 and MCF-7 cells.