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. 2014 Mar 14;7(6):2023–2028. doi: 10.3892/ol.2014.1972

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Copyright © 2014, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Casticin inhibits β-catenin and cyclin D1 protein expression in LCSCs derived from the MHCC97 cell line. (A) β-catenin is highly expressed in CD133⁺ SFCs compared with corresponding PCs. (B) Casticin downregulated the expression of β-catenin in CD133⁺ SFCs of the MHCC97 cell line. (C) Cyclin D1 is highly expressed in CD133⁺ SFCs compared with corresponding PCs. (D) Casticin downregulated the expression of cyclin D1 in CD133⁺ SFCs of the MHCC97 cell line. LCSCs, liver cancer stem cells; CD133, cluster of differentiation 133; SFCs, sphere-forming cells; PC, parental cell.