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. 2014 Jun 9;9(6):e99276. doi: 10.1371/journal.pone.0099276

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© 2014 Clemens et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The comparison is conducted based on the results from the generation of CE for the respective end points. If no CE was generated (according to the strict heterogeneity criteria) a comparison of the respective result of the specific NOAC was applied. Legend: AP, apixaban; BID, twice-daily dosing; CE, common estimate; CE BID, common estimate generated by meta-analysis of DE 150 mg BID and AP 5/2.5 mg BID; CE QD, common estimate generated by meta-analysis of RIVA 20/10 mg QD and EDOX 60/30 mg QD; DE, dabigatran etexilate; EDOX, edoxaban; HR (95% CI), hazard ratio (95% confidence interval); ITT, intention-to-treat analysis; NOACs, novel oral anticoagulants; QD, once-daily dosing; RIVA, rivaroxaban; safety, safety set analysis.