Figure 3. CM-118 inhibits oncogenic c-Met signaling and survival in c-Met-driven H1993 and SNU-5 cells. H1993 (A) or SNU-5 (B) cells were treated for 6 h with various doses of CM-118, 1 μmol/L PF2341066 (PF). Total cell lysates were immunoblotted as indicated. (C) Cell lysates of H1993 or SNU-5 after 6 h treatment with various doses of CM-118, 1 μM PF, or 1 μM AZD8055 (AZD) were immunoblotted. (D) H1993 and SUN-5 cells were treated with various doses of CM-118 for 48 h, then collected for cell cycle analysis.