Figure 6. CM-118 shows in vivo efficacy in xenograft SNU-5, U87MG tumors. (A) Nude mice bearing SNU-5 tumors were dosed orally with vehicle, 50 or 100 mg/kg CM-118. Four hours later, levels of phosphorylated c-Met and c-Met in tumor tissue were analyzed as described in Methods. (B) Tumor bearing mice were dosed orally with vehicle, 50 or 100 mg/kg CM-118 bid (n = 13). Tumor volumes (top) and body weights (bottom) are shown. (C) SNU-5 tumor-bearing mice were treated with vehicle, 12.5 or 25 mg/kg CM-118 bid (n = 5). (D) U87MG tumor-bearing mice were treated with vehicle, 15, 30, or 60 mg/kg CM-118 bid (n = 8). Tumor volumes are shown. Statistical analysis: **P < 0.01; ***P < 0.001. (E) On last day of study in C, mouse plasma (n = 3) were analyzed for CM-118 concentration and 8 h exposure AUC.