Table 2. KRAS mutations spectrum in 670 colorectal cancers.
| Mutation | Frequency | Percentage |
|---|---|---|
| Codon 12 | 505 | 75.1% |
| G12D | 252 | 37.5% |
| G12V | 135 | 20.1% |
| G12C | 46 | 6.8% |
| G12S | 33 | 4.9% |
| G12A | 29 | 4.3% |
| G12R | 10 | 1.5% |
| Codon13 | 130 | 19.3% |
| G13D | 128 | 19.0% |
| G13C | 2 | 0.3% |
| Codon 61 | 17 | 2.5% |
| Q61H | 9 | 1.3% |
| Q61L | 5 | 0.7% |
| Q61K | 1 | 0.1% |
| Q61R | 2 | 0.3% |
| Codon 146 | 18 | 2.7% |
| A146T | 18 | 2.7% |
| Others | 2 | 0.3% |
| c.30_31insGGA, p.G10_A11insG | 1 | 0.1% |
| c.33_34insGGAGCT:p.A11_G12insGA | 1 | 0.1% |
| Total | 672a | 100% |
aA total of 672 KRAS mutations were detected from 670 colorectal tumors. Two tumors harbored double mutations.