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. 2014 Mar 18;15(6):768–776. doi: 10.4161/cbt.28550

Table 4. Comparison of KRAS mutation distribution in reported series.

Studies Current study COSMIC database Rosty 201323 Imamura 201241 De Roock 201042 Chang 200943 Karapetis 200844 Amado 20087 Brink 200331 Samowitz 200021 Andreyev 199811
n = 1506 17316 776 1261 747 228 394 427 737 1416 2214
Mutation rate % 44.5 34.9 28 35.8 36.3 36.4 41.6 43.1 36.8 31.8 37.7
Relative mutation distribution (%) by codon
Codon 12 75.1 79.3 87 74.6 69.3 69.9 63.8 84.2 70 77.9 54
Codon 13 19.1 17.6 13 25.4 20.1 25.3 11.7 15.8 21.6 22.1 16.7
Codon 61 2.5 0.58     5.3 1.2          
Codon 146 2.7 0.19     5 2.4          
Relative mutation distribution (%) by nucleotide substitution
G12D 37.6 35 161 35.2 27.4   35.7 38 26.1 31.1 30.6
G12V 20.0 21.5 95 20.8 19.8   28.1 21.7 24.4 21.4 23.4
G12C 6.7 8.3 44 9.6 7.3     7.6 5.9 9.5  
G12S 4.9 6.3 12 2.6 6.3     7.6 5.6 6.8  
G12A 4.3 6.7 20 4.4 6.9     8.2 5.6 3.5  
G12R 1.5 1.1 8 1.8 1.7     1.6 2.4 0.7  
G13D 18.8 17.4 110 24.1 20.1   11.7 15.8 20.2 20.8 16.7
G13C 0.3   3 0.7         0.3 0.4  
Q61H 1.3 0.3     2.3            
Q61L 0.7 0.2     1            
Q61R 0.3 0.1     1.3            
A146T 2.7 0.2     5