Figure 3. Effects of NAcc core and shell inactivation on cue-induced reinstatement.

Top panels demonstrate that rats were showing robust lever-pressing on the VR-5, FI-20 schedule by the completion of training (top panels). The middle panels demonstrate a significant effect of NAcc inactivation on cue-induced reinstatement on the previously active lever, regardless of whether the muscimol/baclofen cocktail was injected into the core or the medial shell. There were no changes in pressing on the inactive lever across extinction and reinstatement test conditions. Bottom panels represent the pattern of lever pressing across the reinstatement period and suggest that drug treatment blocked reinstatement early in the session, which then extinguished across time during all test days. Statistical symbols are consistent with those used in Fig. 2.