Figure 4. Although NAcc core and shell inactivation caused a main effect of drug on cue-induced reinstatement (Fig. 3), there was also a significant three-way interaction.

As shown here, the rats who received muscimol/baclofen injections in the NAcc shell on the first reinstatement day did not reinstate food-seeking behavior on the second test when they received saline injections. The star represents a significant difference in responding between animals that received saline injections on the first or second test day. In contrast, rats with NAcc core inhibition showed attenuated reinstatement regardless of which day the drug was given.