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. 2014 Jun 9;9(6):e99575. doi: 10.1371/journal.pone.0099575

Figure 2. Macrophage depletion reduces body weight and fat mass.

Figure 2

Male LysMCre/iDTR mice were fed (A, C, and E) a chow diet (n = 7) or (B, D, and F) a HF diet (n = 5) for 6 wks and i.p. injected with DT (10 ng/g) or saline every other day. For chow-fed mice, DT injection was stopped at day 25 which is indicated by arrows. (A and B) Body weight was measured every other day and calculated as a percent change compared to day 0 of saline or DT injection (C and D) Fat mass and (E and F) lean body mass were measured using an EchoMRI scanning device when mice were at fed state and these masses were calculated as a percent change compared to day 0 of saline or DT injection. Data are presented as mean ± SEM. *P<0.05 vs. saline-treated mice.