Table 1.
Boron biodistribution of cis-ABCPC, trans-ABCPC and BPA in B16 melanoma bearing mice. Boron concentrations are expressed in ppm wet weight (mean ± SD).
| Compounda | Boron concentration (μg/g)b |
Ratios |
|||
|---|---|---|---|---|---|
| Tumor | Brain | Blood | T/Br | T/Bl | |
| cis-ABCPC | 16.4 ± 9.0 | 4.1 ± 3.5 | 1.0 ± 0.9 | 4.0 | 16.4 |
| trans- ABCPC | 13.0 ± 2.4 | 3.3 ± 1.1 | 3.3 ± 1.1 | 3.9 | 3.9 |
| BPA | 28.6 ± 4.6 | n.d. | 5.3 ± 0.8 | n.d. | 5.4 |
a
All compounds at a dose of 24 mg B equivalent/kg b.w. were administered i.p. and animals were euthanized at 2.5 hrs post-dosing.
b
Boron concentrations were determined by ICP-OES for groups of 4 mice. “n.d. is not determined.