Table 3.
Boron biodistribution of cis-ABCPC and BPA in F98 Glioma bearing Rats.
| Boron Concentrations (μg/g wt) ± SDc | Ratios | ||||||
|---|---|---|---|---|---|---|---|
| Test Agentb | Tumor | Ipsilat. Brain |
Contralat. Braind |
Blood | Kidney | T/Bl | T/Br |
|
|
|
||||||
| cis-ABCPC | 26.2 ± 9.7 | 7.9 ± 3.2 | 4.4 ± 0.5d | 6.7 ± 1.5 | 33.6 ± 7.7 | 3.9 | 6.0 |
|
|
|
||||||
| BPA | 21.5 ± 8.4 | 8.8 ± 2.1 | 6.5 ± 0.5 | 5.1 ± 1.4 | 30.1 ± 5.5 | 4.2 | 3.3 |
a
F98 glioma cells (104) were implanted into the right caudate nucleaus of syngeneic Fischer rats.
b
The test agents were administered i.p. at a dose of 250 mg/kg b.w. and rats were euthanized 2.5 hrs post-dosing.
c
Boron concentrations were determined by ICP-OES and mean and standard deviations were calculated from groups of 4 rats.
d
Contralateral brain tissue contained significantly less (p <0.05) boron in rats that received cis-ABCPC compared to BPA.