Table 3. Non-enriched Rho regulators with known endothelial function.
| Gene Name | Alternative names | Function |
|---|---|---|
| ARAP1 | CENTD2 | Highly enriched in renal vasculature. 207 |
| ARHGAP35 | GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP | Modulates cell adhesion and F-actin organization to protect barrier function and mediates transcriptional control of retinal angiogenesis. 105 - 110 |
| ARHGAP5 | GFI2, RhoGAP5, p190-B, p190BRhoGAP | Extracellular matrix degradation. 208 |
| OCRL | RP3–454M7.1, INPP5F, LOCR, NPHL2, OCRL-1, OCRL1 | Expressed in Schlemm's canal ocular endothelial cells. 209 |
| PIK3R1 | AGM7, GRB1, p85, p85-ALPHA | Regulates migration of endothelial tip cells during zebrafish angiogenesis and controls lymphangiogenesis in mice. 210 , 211 |
| PIK3R2 | MPPH, P85B, p85, p85-BETA | Negatively regulates VEGF signaling in sprouting angiogenesis and vascular integrity. 212 |
| STARD13 | RP11–81F11.1, ARHGAP37, DLC2, GT650, LINC00464 | Mediates endothelial adhesion and migration and suppresses experimentally-induced angiogenesis in mouse models. 79 |
| ARHGEF1 | GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 | Inducer of endothelial permeability via regulation of cell adhesion.174-178 |
| ARHGEF11 | RP11–356J7.2, GTRAP48, PDZ-RHOGEF | Mediator of Semaphorin 4D-induced endothelial signaling in adhesion and migration.165 |
| ARHGEF17 | P164RHOGEF, TEM4, p164-RhoGEF | Important for endothelial migration and monolayer integrity via cytoskeletal-dependent regulation of cell adhesion.180,181 |
| ARHGEF2 | RP11–336K24.3, GEF, GEF-H1, GEFH1, LFP40, P40 | Regulator of endothelial permeability induced by agonists or by mechanical strain.183,184 |
| ARHGEF26 | CSGEF, HMFN1864, SGEF | Regulator of endothelial docking structures during transmigration of leukocytes.186,187 |
| ARHGEF4 | ASEF, ASEF1, GEF4, STM6 | Involved in experimentally-induced angiogenesis in mouse models.202 |
| ARHGEF6 | RP3–527F8.4, COOL2, Cool-2, MRX46, PIXA, α-PIX, alphaPIX | Regulator of endothelial migration and adhesion.213 |
| DOCK1 | RP11–82L9.1, DOCK180, ced5 | Regulates polarized membrane protrusions and endothelial migration during vascular development.188,189 |
| ELMO1 | CED-12, CED12, ELMO-1 | Regulates polarized membrane protrusions and endothelial migration during vascular development.188,190 |
| FGD1 | RP1–112K5.1, AAS, FGDY, MRXS16, ZFYVE3 | Regulates TGF-β-induced endothelial podosome formation and extracellular matrix degradation.214 |
| ITSN2 | PRO2015, SH3D1B, SH3P18, SWA, SWAP | Caveola endocytosis.152 |
| PLEKHG5 | RP4–650H14.3, CMTRIC, DSMA4, GEF720, Syx, Tech | Regulator of endothelial cell migration, cell-cell adhesion and angiogenesis.86-88 |
| PREX1 | P-REX1 | Regulator of cell adhesion, Weibel-Palade body secretion, and required for inflammation-induced permeability.191,193,194 |
| PREX2 | 6230420N16Rik, DEP.2, DEPDC2, P-REX2 | Regulator of endothelial cell migration.192 |
| TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1 | Regulation of endothelial cell-cell adhesion and redox signaling.145,197-201 |
| VAV3 | VAV-3; guanine nucleotide exchange factor VAV3; vav 3 oncogene | Mediator of ephrin-induced angiogenesis and tumor-associated angiogenesis.147,148 |
Non-enriched Rho regulators with known endothelial function. This table shows the GAPs (bold) and GEFs (unbold) that are not specifically enriched in endothelium based on gene expression analysis, but which are, based on literature, known to function in endothelial cells. Gene name, alternative names and a summary of their endothelial function including references are shown.