Figure 2. Molecular details of CCM1 biological function. Loss of CCM1 results in release of β-catenin from VE-cadherin, and subsequent activation of TCF/LEF-dependent transcription (1). Interaction of ICAP1 to β1-integrins disturbs focal adhesions by preventing binding of talin and kindlin. CCM1 inhibits binding of ICAP1 to β1-integrins and ICAP1 stabilizes CCM1 followed by nuclear translocation of the complex (2). CCM1 is located to the plasma membrane through interaction with the HEG1 transmembrane receptor.