Table 1.
Association of combined CREB and pCREB upregulation with clinicopathological features of 130 hepatocellular carcinoma patients
| Clinicopathological features | Case | CREB-high/pCREB-high (n, %) | P |
|---|---|---|---|
| Age (years) | |||
| ≤50 | 72 | 32 (44.44) | – |
| >50 | 58 | 28 (48.28) | |
| Sex | |||
| Male | 96 | 44 (45.83) | – |
| Female | 34 | 16 (47.06) | |
| Serum AFP | |||
| Positive (≥400 μg/L) | 72 | 40 (55.56) | 0.02* |
| Negative (<400 μg/L) | 58 | 20 (34.48) | |
| Tumor stage | |||
| T1 | 23 | 0 | <0.001** |
| T2 | 40 | 10 (25.00) | |
| T3 | 52 | 35 (67.31) | |
| T4 | 15 | 15 (100.00) | |
| Tumor grade | |||
| G1 | 31 | 8 (25.81) | 0.01* |
| G2 | 76 | 34 (44.74) | |
| G3 | 23 | 18 (78.26) | |
| Growth pattern | |||
| Trabecular | 101 | 45 (44.55) | – |
| Nontrabecular | 29 | 15 (51.72) | |
| Cirrhosis | |||
| Yes | 86 | 40 (46.51) | – |
| No | 44 | 20 (45.45) | |
| Underlying liver disease | |||
| Alcoholic | 25 | 12 (48.00) | – |
| Hepatitis B | 49 | 22 (44.90) | |
| Hepatitis C | 35 | 16 (45.71) | |
| Unknown | 21 | 10 (47.62) | |
Notes:
*
P<0.05
**
P<0.001.