Table 1. Baseline characteristics of acute ischemic stroke patients and control cases.
| Characteristics | Patients(n = 168) | Control (n = 100) | pa |
| Age (years), median(IQR) | 72(62–83) | 72(63–84) | NS |
| Female sex (%) | 46.4 | 46 | NS |
| The time from symptom to admission (hours), median(IQR) | 4.8(3.3–11.5) | — | |
| Stroke severity at admission, median NIHSS score (IQR) | 7(3–12) | — | |
| Infarct volume(mL, IQR; n = 125) | 15(8–28) | — | |
| Vascular risk factors no. (%) | |||
| Hypertension | 72.0 | — | |
| Diabetes mellitus | 42.9 | — | |
| Coronary heart disease | 32.7 | — | |
| Hypercholesterolemia | 41.1 | — | |
| Family history for stroke | 23.2 | 8 | 0.002 |
| Alcohol abuse | 8.9 | 6 | NS |
| Smoking habit | 18.5 | 13 | NS |
| Clinical findings median(IQR) | |||
| BMI (kg m−2) | 25.3(21.8–28.4) | 23.9(21.8–26.3) | 0.012 |
| Heart rate (beats min−1) | 81(70–94) | 79(69–90) | NS |
| Temperature (°C) | 36.9(36.5–37.4) | 36.5(36.2–36.8) | NS |
| Systolic blood pressure(mmHg) | 159(142–173) | 128(105–134) | <0.0001 |
| Diastolic blood pressure(mmHg) | 94(81–101) | 82(74–87) | 0.003 |
| Stroke etiology no. (%) | — | ||
| Small-vessel occlusive | 23.2 | ||
| Large-vessel occlusive | 21.4 | ||
| Cardioembolic | 31.0 | ||
| Other | 12.5 | ||
| Unknown | 11.9 | ||
| Stroke syndrome no. (%) | — | ||
| TACS | 18.5 | ||
| PACS | 38.1 | ||
| LACS | 19.0 | ||
| POCS | 24.4 | ||
| Laboratory findings (median, IQR) | |||
| Leucocyte count (×103 m L−1) | 8.6(7.2–10.1) | 8.2(6.8–8.9) | 0.042 |
| Glucose(mmol L−1) | 6.59(5.51–7.49) | 5.48(5.02–5.99) | 0.002 |
| Hs-CRP(mg dL−1) | 0.66(0.31–1.03) | 0.25(0.12–0.36) | <0.0001 |
| HCY(umol L−1) | 18.9(13.4–25.7) | 12.8(10.2–15.3) | 0.006 |
| D-dimer(mg L−1) | 0.95(0.45–2.45) | 0.30(0.15–0.69) | <0.0001 |
| IGF-1(ng mL−1) | 127(106–156) | 155(138–176) | <0.0001 |
IQR, interquartile range; TACS, total anterior circulation syndrome; LACS, lacunar syndrome; PACS, partial anterior circulation syndrome; POCS, posterior circulation syndrome; NIHSS, National Institutes of Health Stroke Scale; Hs-CRP, High-sensitivity -C-reactive protein; NS, not significant.
a
p value was assessed using Mann-Whitney U test or χ2 test.