Figure 5.

Association of endoglin with different signaling cascades. The concentrical circles display the hierarchy of signaling. Signaling starts at the membrane with receptors and adaptors (inner two circles). The next circle represents activated intermediates and adaptors. Thereafter, target genes are indicated. These are involved in shaping a cellular response which is part of a complex process (last circle). Partially open radial lines indicate that the corresponding molecules interact or interaction of molecules is mediated by the protein displayed on the radial line (LRP-1). The green font indicates items addressed in liver cells which are modulated by endoglin.