Figure 1.

Flaviviruses target cell death and survival pathways. Extrinsic and intrinsic cell death pathways are activated during viral infection (d, w, and j are for dengue, west nile and japanese encephalitis live viruses respectively) or expression of specific viral proteins (d, w and j with viral protein). Expression of multiple genes including non-coding microRNAs (miRNA) also induced during flavivirus infections. FLaviviruses also activate ER stress signaling and increase metabolism related products (ROS and NO). TNF: Tumor necrosis factor; EGFR: Epidermal growth factor receptor.