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Figure 2. HCT116 cells without endogenous DNA2 expression are sensitive to formaldehyde. (A) Western blot showing DNA2 depletion in HCT116 DNA2flox/−/− cells after addition of tamoxifen (4-OHT). (B) Cell proliferation is impaired after knockdown of endogenous DNA2. (C) DNA2-knockout cells are sensitive to formaldehyde. Error bars indicate mean ± SEM for n ≥ 2 independent experiments.
