Table 1. Prevalence of Gray Zone Alleles in Population Studies.

Author	Defined Gray Zone	Age	Gender	No. of Patients	Location	Gray Zone Rate (%)
Rousseau et al.56	35–54	Not reported	Women	10,624	Canada	0.4
Dawson et al.57	40–59	Newborns	Men and women	2,000	Spain	2.7
Zhong et al.58	41–54	Not reported	Men	56	USA	1.7
Spence et al.59	40–59	(Pregnant women of advanced maternal age)	Women	745	USA	2.2
Drasinover et al.52	50–55	Not reported	Women	10,587	Israel	0.5
Dombrowski et al.60	40–54	Not reported	Men	10,572	Canada	0.3
Penagarikano et al.22	41–54	Not reported	Men	158	Spain	3.2
Cronister et al.61	45–54	Not reported	Women	29,103	USA	0.7
Tzeng et al.62	45–54	Newborns	Boys	10,046	Taiwan	0.7
Metcalfe et al.63	45–54	>18 years	Women	338	Australia	0.7
Levesque et al.64	45–54	Mother-newborn pairs	Women, boys, and girls	24,449	Canada	1.2
Fernandez-Carvajal et al.14	45–54	Newborns	Boys and girls	5,267	Spain	3.8
Otsuka et al.65	40–50	Not reported	Men and women	946	Japan	0.6
Tassone et al.19	45–54	Newborns	Boys and girls	14,207	USA	1.2
Seltzer et al.66	45–54	67–68 years	Men and women	6,747	USA	2.6