Table 4.
Variable | All Participants |
Patient Cases (n = 159)† |
Controls (n = 181)† |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Unadjusted (N = 346) |
Adjusted (n = 343)‡§ |
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OR | 95% CI | P | OR | 95% CI | P | Adjusted OR | 95% CI | P | Adjusted OR | 95% CI | P | |
Patient case (v control) | 0.93 | 0.51 to 1.71 | .83 | 0.74 | 0.37 to 1.47 | .39 | — | — | ||||
Age, per 1-year increase | 1.12 | 1.07 to 1.17 | < .001 | 1.10 | 1.05 to 1.15 | < .001 | 1.09 | 1.02 to 1.18 | .02 | 1.10 | 1.03 to 1.18 | .003 |
Education, per 1-year increase | 0.77 | 0.67 to 0.88 | < .001 | 0.81 | 0.69 to 0.95 | .008 | 0.83 | 0.64 to 1.08 | .17 | 0.80 | 0.65 to 1.00 | .050 |
Nonwhite race (v white, non-Hispanic)‖ | 2.90 | 1.51 to 5.60 | .002 | 3.38 | 1.57 to 7.28 | .002 | 5.45 | 1.57 to 18.9 | .008 | 2.91 | 0.98 to 8.63 | .054 |
≥ 2 comorbidities (v < 2) | 2.81 | 1.50 to 5.27 | .001 | 2.31 | 1.14 to 4.69 | .020 | 8.77 | 2.06 to 37.4 | .003 | 0.98 | 0.39 to 2.49 | .97 |
Mastectomy (v lumpectomy)¶ | — | — | 0.59 | 0.16 to 2.25 | .44 | — |
NOTE. ORs are from logistic regression models. Variables not considered in models because they were not significantly related to impairment: current physical (P = .22) or emotional function (P = .31), depression (P = .99), anxiety (P = .20), fatigue (P = .34), smoking (P = .93), physical activity (P = .33), and presence of APOE e4 allele (P = .21).
Abbreviation: OR, odds ratio.
Cognitive impairment defined as any one domain z score two SDs or two domain z scores 1.5 SDs below control mean.
Models stratified by patient case or control status included because of interaction between patient case or control status and comorbidity.
All adjusted ORs adjusted for covariates shown plus recruitment site.
Three patient cases were missing surgery or refused surgery and are not included.
Nonwhite race includes black, Hispanic, Asian American, and Pacific Islander.
Results for unadjusted association between surgery and impairment in patient case group: OR, 1.03; 95% CI, 0.41 to 2.60; P = .951.