Figure 3.
Stroke induces rapid nonoverlapping changes in gene expression in endothelial cells within injured regions in adults and neonates. Heatmaps obtained in endothelial cells isolated from injured adult and neonatal brains 24 hours after transient 3 hours MCAO, as described in Fernandez et al.77 Heatmap visualization from a total of 31,042 probe sets shows that the expression levels of endothelial genes are markedly changed in injured regions compared with the corresponding contralateral anatomic regions in the same rats in each age group but that the patterns of changes are distinct after adult and neonatal stroke. The expression levels of genes are indexed by color.