Table 2. Multiple linear regression analysis of cerebral hemodynamics.

Model	Variable	Overall model	Model improvement	B	95% CI
		R2 (P value)	ΔR2 (P value)		Lower	Upper
Dependent variable: Total cerebral blood flow (mL/100 g per minute)
1	Age	0.10 (<0.01)	0.10 (<0.01)	−0.26	−0.44	−0.09
2	Age2	0.11 (0.01)	0.01 (0.49)	−0.004	−0.016	0.008
3	Sex (female)	0.62 (<0.001)	0.51 (<0.001)	17.8	14.3	21.4
4	Diastolic blood pressure	0.64 (<0.001)	0.02 (0.03)	−0.29	−0.56	−0.03
Dependent variable: Systolic cerebral blood flow velocity (%)
1	Age	0.22 (<0.001)	0.22 (<0.001)	0.32	0.19	0.46
2	Age2	0.34 (<0.001)	0.12 (<0.001)	0.016	0.008	0.024
3	Sex (female)	0.34 (<0.001)	0.001 (0.81)	0.47	−3.41	4.34
4	Carotid pulse pressure	0.39 (<0.001)	0.05 (0.02)	0.34	0.06	0.61
Dependent variable: Diastolic cerebral blood flow velocity (%)
1	Age	0.42 (<0.001)	0.42 (<0.001)	−0.22	−0.28	−0.16
2	Age2	0.47 (<0.001)	0.05 (0.01)	−0.005	−0.009	−0.001
3	Sex (female)	0.52 (<0.001)	0.05 (<0.01)	−2.41	−4.06	−0.76
4	Carotid pulse pressure	0.59 (<0.001)	0.07 (0.001)	−0.20	−0.32	−0.09
5	Carotid-femoral PWV	0.61 (<0.001)	0.02 (0.03)	0.64	0.06	1.22
Dependent variable: Pulsatile cerebral blood flow velocity (%)
1	Age	0.32 (<0.001)	0.32 (<0.001)	0.54	0.37	0.72
2	Age2	0.43 (<0.001)	0.11 (<0.001)	0.021	0.010	0.031
3	Sex (female)	0.44 (<0.001)	0.01 (0.25)	2.88	−2.09	7.84
4	Carotid pulse pressure	0.50 (<0.001)	0.06 (<0.01)	0.54	0.20	0.89
5	Carotid AIx	0.55 (<0.001)	0.05 (<0.01)	−0.26	−0.45	−0.08

AIx, augmentation index; B, unstandardized beta coefficient; CI, confidence interval; PWV, pulse wave velocity; R², coefficient of determination.

Age, age², and sex were forced to enter sequentially. Stepwise method was used to enter central hemodynamic variables.