Table 2. Statistical description of the distribution of V _T and K _b estimates (across all regions and subjects).

VT (mL/cm3)	HAB		MAB		Kb (1/min)	HAB	MAB
	2TCM	2TCM-1K	2TCM	2TCM-1K		2TCM-1K
Mean	4.63	1.64	3.35	1.05	Mean	0.29	0.21
s.d.	1.02	0.34	0.83	0.24	s.d.	0.12	0.10
CV (%)	22	21	25	23	CV (%)	42	46
Min	2.59	0.85	1.93	0.63	Min	0.14	0.10
Max	7.77	2.60	5.75	1.75	Max	0.79	0.76
Median	4.61	1.64	3.20	0.99	Median	0.26	0.20
MAD	0.81	0.26	0.65	0.19	MAD	0.09	0.06
CV (%)	18	16	20	20	CV (%)	32	32

Abbreviations: CV, coefficient of variation; HAB, high-affinity binder; MAB, mixed-affinity binder; 2TCM, two-tissue compartmental model.

V_T values have been obtained with 2TCM and 2TCM-1K. K_b Values have been obtained with 2TCM-1K. The values are reported separately for homozygous high-affinity binders (HAB, 8 subjects) and heterozygous mixed-affinity binders (MAB, 10 subjects). s.d. and MAD refer to standard deviation and median absolute deviation respectively.