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. 2014 May 23;5:3817. doi: 10.1038/ncomms4817

Figure 1. Synaptic input modulates the spiking threshold of dentate granule cells.

Figure 1

(a) Inset: experiment diagram. Upper traces: pattern of electric stimuli applied with varied amplitudes to the presynaptic perforant fibres, as depicted. Lower traces: the corresponding somatic voltage recordings (colour-coded accordingly) show a characteristic one-cell example. (b) Somatic voltage traces in a expanded as shown by dashed lines; arrows depict spiking threshold values (VT) that visibly increase with lower rates of perforant fibre excitation-induced somatic depolarization. (c) Multiple trials recorded, in an arbitrary sequence, in five individual cells show strong correlation between the rate of depolarization (set by the synaptic input strength) and the granule cell-spiking threshold (VT). Experiments carried out at 33 °C.