Fig. 4.

The α7AChR agonist PHA-543613 HCl inhibits P. gingivalis-induced phosphorylation of the NF-κB p65 subunit at serine 536 and 468. The percentage of the NF-κB p65 subunit phosphorylated at serine residues 536 (a) and 468 (b) was calculated. The data represent the mean angular-transformed percentage of NF-κB p65 subunit phosphorylated at each residue with the SD. The data are derived from duplicate wells of 3 independent experiments (n = 3). Statistical analysis was performed by ANOVA and a post hoc Holm−Bonferroni (H–B) corrected least significant difference test (*P < 0.05/H–B)