Table 4.
Change in cognitive function predicted through change in white matter, and its interactions with age and status. Sex and ICV were fixed variables while subject was the random variable.
| Interactions |
ROI-by-age |
ROI-by-status |
ROI-by-status -by-age |
ROI-by-age |
ROI-by-status |
ROI-by-status -by-age |
ROI-by-age |
ROI-by-status |
ROI-by-status -by-age |
ROI-by-age |
ROI-by-status |
ROI-by-status -by-age |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Corpus callosum | Inferior frontal | Superior frontal | Middle frontal | |||||||||
| TMT-A | 0.036 | 0.074 | 0.082 | 0.005 | 0.017 | 0.015 | 0.023 | 0.052 | 0.046 | 0.007 | 0.083 | 0.062 |
| 2.202 | –1.802 | 2.202 | 3.070 | 2.541 | –2.593 | 2.397 | 2.027 | –2.086 | 2.902 | 2.070 | –1.944 | |
| DF | 0.033 | 0.005 | 0.002 | 0.187 | 0.027 | 0.044 | 0.253 | 0.027 | 0.032 | 0.358 | 0.030 | 0.047 |
| –2.257 | –3.087 | 3.379 | –1.354 | –2.341 | 2.111 | –1.168 | –2.334 | 2.264 | –0.936 | –2.288 | 2.085 | |
| TMT-B | 0.699 | 0.036 | 0.078 | 0.018 | 0.425 | 0.997 | 0.015 | 0.323 | 0.226 | 0.092 | 0.118 | 0.292 |
| –0.390 | –2.207 | 1.836 | 2.520 | –0.809 | –0.004 | 2.583 | –1.007 | 1.240 | 0.631 | –1.472 | 1.075 | |
| CVLT | 0.370 | 0.071 | 0.042 | 0.570 | 0.937 | 0.964 | 0.420 | 0.813 | 0.837 | 0.904 | 0.962 | 0.884 |
| –1.860 | –2.028 | 2.124 | 0.605 | 0.108 | –0.005 | 0.798 | 0.223 | –0.193 | 0.105 | –0.053 | –1.860 | |
| DB | 0.302 | 0.114 | 0.044 | 0.758 | 0.433 | 0.551 | 0.796 | 0.515 | 0.625 | 0.545 | 0.403 | 0.362 |
| –1.053 | –1.637 | 2.123 | –0.312 | –0.796 | 0.604 | 0.261 | –0.661 | 0.495 | –0.614 | –0.850 | 0.928 | |
|
Inferior parietal |
Supramarginal |
Superior parietal |
Total white matter |
|||||||||
| TMT-A | 0.012 | 0.160 | 0.117 | 0.012 | 0.160 | 0.117 | 0.011 | 0.180 | 0.094 | 0.052 | 0.209 | 0.192 |
| 2.689 | 1.444 | –1.614 | 3.335 | 2.385 | –2.432 | 2.720 | 1.375 | –1.733 | 2.030 | 1.286 | –1.335 | |
| DF | 0.117 | 0.031 | 0.047 | 0.117 | 0.031 | 0.047 | 0.60 | 0.173 | 0.279 | 0.157 | 0.026 | 0.023 |
| –1.620 | –2.275 | 2.080 | –1.092 | –1.766 | 1.687 | –0.523 | –1.400 | 1.104 | –1.456 | –2.358 | 2.407 | |
| TMT-B | 0.027 | 0.099 | 0.262 | 0.034 | 0.409 | 0.262 | 0.882 | 0.255 | 0.359 | 0.102 | 0.256 | 0.114 |
| 2.330 | –1.703 | 1.146 | 2.220 | –0.837 | 0.877 | 0.149 | –1.162 | 0.932 | 0.090 | –1.953 | 1.634 | |
| CVLT | 0.897 | 0.838 | 0.707 | 0.897 | 0.838 | 0.707 | 0.893 | 0.962 | 0.930 | 0.937 | 0.988 | 0.694 |
| 0.118 | –0.204 | 0.388 | –0.335 | –0.462 | 0.679 | –0.135 | 0.048 | 0.721 | –0.036 | 0.029 | 0.360 | |
| DB | 0.844 | 0.699 | 0.743 | 0.844 | 0.699 | 0.743 | 0.835 | 0.973 | 0.812 | 0.302 | 0.114 | 0.417 |
| –0.198 | –0.391 | 0.331 | 0.183 | 0.026 | 0.023 | 0.290 | 0.210 | –0.240 | –0.485 | –0.480 | 0.824 | |
Significant p values of <0.05 have been presented in bold font.
T-values for significance have been presented below in italics.