Figure 5.

Infusion of AraC and GCV Leads to Complete but Temporary Loss of Neurospheres

(A) AraC-only infusion for 7 days into TK mice resulted in a 99% ± 0.5% loss in neurospheres relative to saline-infused controls when sacrificed immediately after infusion (day 7). Neurospheres returned to control values by 3 days after AraC infusion (n = 3–6 mice/group/time point).

(B) AraC and GCV infusion eliminated TK neurosphere formation immediately after the infusion (day 10), but returned with longer survival times (n = 3–5 mice/group). Controls are NT mice that received infusions.

Data are shown as mean ± SEM; ^∗p < 0.0001. See also Figure S4.