Table 1.
Chromatin Immunoprecipitation Sequencing Data Showing Transcription Factor Binding Sites in Regulatory Regions of Intercellular Signaling Genes Selectively Expressed in Top, Triple-High, or High Cell Subpopulations, Based on ENCODE Peak Calls in H1 ESC ±10 kb of UCSC Transcript Models Using hg19 Assembly
| NANOG | RAD21 | POU5F1 | BCL11A | TCF12 | USF1 | |
|---|---|---|---|---|---|---|
| NODAL | +a | +a | +a | − | +,a,b +a | − |
| CER | +a,b | − | − | +a,b | +a,b | − |
| GDF3c | +a | +,a +a | +a,b | +a,b | − | − |
| ACVRIB | +a,b | +a | − | − | − | − |
| LEFTY1d | +,a,b +a | +a | +,a +a | +a,b | +a,b | +a,b |
| TDGF1e | +,a,b +a,b | − | − | − | +,a,b +a,b | − |
| CD9 | +a,b | +a,b | +a,b | − | +a,b | +a |
| ERBB3 | − | +,a,b +a | − | − | +a,b | +a,b |
| EPCAM | +a,b | − | − | − | +,a,b +a,b | − |
| EPHA1 | − | +,a,b +a,b | − | − | − | − |
| HAS3 | +,a,b +a,b | +,a,b +a,b | − | − | − | +,a,b +a,b |
| CDH3 | − | +a | − | − | − | +a,b |
| LCK | +a,b | +a,b | − | − | +a,b | − |
Multiple entries indicate more than one binding site in the regulatory region.
a
DNAase-hypersensitive site.
b
H3K27Ac.
c
NANOG site in distal regulatory region (Levasseur et al., 2008).
d
Approximately −20 kb relative to start of transcription.
e
TDGF1 is included because of its role as a coreceptor for GDF3 and NODAL.