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. 2014 May 15;2(6):825–837. doi: 10.1016/j.stemcr.2014.04.005

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

hNPC-Mediated Clinical Recovery Is Associated with Dampened Neuroinflammation at Day 21 Pt

(A) Clinical recovery following hNPC transplantation was associated with reduced neuroinflammation indicated by H&E staining of spinal cord sections (upper panel, control; lower panel, hNPC-treated).

(B and C) Immunohistochemical staining demonstrated reduced (B; upper panel, control; lower panel, hNPC-treated) macrophage infiltration/microglia activation (IBA-1 reactivity, brown) and (C) CD3-positive lymphocytes (pan-T cell marker, Alexa 488/green staining) within spinal cords of hNPC-treated and control mice (upper panel, control; lower panel, hNPC-treated).

(D) Quantification of IBA-1 and CD3-reactive cells indicated a significant reduction in macrophage/microglia and CD3-positive cells following hNPC transplantation compared to control mice. Data are representative of at least two independent experiments with a minimum of three mice per group; data are presented as averages ± SEM. Mann-Whitney t tests were used to determine the p values.