Table 1.
Top 10 cell surface genes driving classification.
| Identifier | Gene name | Description | PC | Fold-change |
|---|---|---|---|---|
| SURFACE T-ALL MARKERS | ||||
| 213539_at | CD3D | CD3d molecule, delta chain of TCR/CD3 | 0.97 | 53.6 |
| 214551_s_at | CD7 | CD7 molecule | 0.94 | 17.95 |
| 205456_at | CD3E | CD3e molecule, epsilon chain of TCR/CD3 | 0.93 | 17.52 |
| 226246_at | KCTD1 | K channel tetramerization domain containing 1 | 0.92 | 7.87 |
| 211796_s_at | TRBC2 | T-cell receptor beta constant 2 | 0.91 | 61.21 |
| 226245_at | KCTD1 | K channel tetramerization domain containing 1 | 0.91 | 10.55 |
| 206545_at | CD28 | CD28 molecule | 0.91 | 27.11 |
| 227236_at | TSPAN2 | Tetraspanin 2 | 0.9 | 10.94 |
| 217147_s_at | TRAT1 | TCR-associated transmembrane adaptor 1 | 0.89 | 28.59 |
| 220253_s_at | LRP12 | LDLR-related protein 12 | 0.88 | 9.55 |
| SURFACE B-ALL MARKERS | ||||
| 206398_s_at | CD19 | CD19 molecule | −0.96 | 0.03 |
| 226878_at | HLA-DOA | MHC class II, DO alpha | −0.92 | 0.07 |
| 205297_s_at | CD79B | CD79b molecule, Ig-associated beta | −0.9 | 0.07 |
| 228831_s_at | GNG7 | G-protein, gamma 7 | −0.9 | 0.07 |
| 209374_s_at | IGHM | Immunoglobulin heavy constant mu | −0.89 | 0.06 |
| 223533_at | LRRC8C | Leucine-rich repeat containing 8 family, C | −0.89 | 0.11 |
| 220068_at | VPREB3 | Pre-B lymphocyte 3 | −0.89 | 0.02 |
| 38521_at | CD22 | CD22 molecule | −0.88 | 0.24 |
| 207857_at | LILRA2 | Leukocyte ig-like R, subfam. A (w/TM domain), 2 | −0.87 | 0.06 |
| 217478_s_at | HLA-DMA | MHC, class II, DM alpha | −0.87 | 0.05 |
Genes were clustered, and then ordered according to Pearson correlation co-efficient (PC, gene vs. outcome). The genes scoring as a positive (T-ALL markers) or negative (B-ALL markers), confirm the original designation in GEO.