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. 2014 May 30;7:9. doi: 10.1186/1755-1536-7-9

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Copyright © 2014 Das et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Antagonism of the MCP-1 receptor (CCR2) slowed C5a mediated HSC migration. HSC on day 8 of culture were used in a two-dimensional wound healing assay (A,B). Cells were pre-treated with or without a CCR2 receptor antagonist, 227016 (10 nM), for 30 min and then challenged with C5a (10 ng/mL) and/or PDGF (50 ng/mL). Images were captured at 0 h, 10 h, and 24 h following stimulation. Gap width was analyzed by Wimasis image analysis software. Values represent means ± SEM, N = 4. Values with different superscripts are significantly different from each other.