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. 2014 May 24;11:95. doi: 10.1186/1742-2094-11-95

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Copyright © 2014 Neher et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Peripheral levels of selected biomarkers and inflammatory mediators in wild-type (WT) and Cr2^-/- mice at 24 hours after closed head injury or sham surgery. Serum and plasma samples were analyzed by mouse-specific ELISA. Final mediator concentrations were normalized by total protein content of the samples, as described in the Materials and methods section. Head-injured mice showed a significant increase in mediator levels at 24 hours, compared to sham-injured animals (*P <0.05). However, there was no difference in concentrations between head-injured WT and Cr2^-/- mice. Data are shown as mean values ± SD and are representative of n = 22 WT and n = 13 Cr2^-/- mice.