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MeV-specific small-molecule inhibitors with proposed or known molecular target.
| Compound | Active Concentration |
Target | Ref. |
|---|---|---|---|
| 5′-Fluoro-5′- deoxyaristeromycin |
13 μM | S-adenosylhomocysteine hydrolase |
(93) |
| Coumarin analogs | 0.6 μM | possibly RdRp | (95) |
| AS-48 | 0.6-2 μM (wild type isolates) |
MeV fusion protein | (97, 98, 147) |
| ERDRP-0519 | ~60 nM (wild type isolates) |
L protein subunit of the MeV RdRp complex |
(102, 105, 106) |
