Table 2.
LTP enhancement without memory enhancement
| Mutant | LTP phenotypes | Memory phenotypes | Reference |
|---|---|---|---|
|
Psd-95 KO |
Enhanced CA1 LTP |
Impaired in MWM |
[129] |
|
Limk-1 KO |
Enhanced CA1 LTP |
Normal initial learning, impaired reversal learning in MWM |
[134] |
|
Syndecan-3 KO |
Enhanced CA1 LTP |
Impaired in MWM |
[135] |
|
PTPδ KO |
Enhanced CA1 and CA3 LTP |
Impaired in MWM, RAM |
[136] |
|
IRSp53 KO |
Enhanced CA1 LTP |
Impaired in MWM, ORT |
[137] |
|
G
iα1
KO |
Enhanced CA1 LTP |
Impaired in CFC, PA, ORT; but normal in MWM |
[138] |
|
Tropomodulin-2 KO |
Enhanced CA1 LTP |
Impaired in CFC, MWM |
[139] |
|
Dystrophin KO |
Enhanced CA1 LTP |
Impaired in MWM, ORT |
[140] |
|
Tsc2 KO |
Enhanced CA1 LTP |
Impaired in MWM, CFC* |
[114] |
|
GluR2 (GluA2) KO |
Enhanced CA1 LTP |
Impaired in MWM |
[141,142] |
|
Fmr2 KO |
Enhanced CA1 LTP |
Impaired in CFC, but normal in MWM |
[133] |
|
dnPAK Tg |
Enhanced cortical LTP |
Impaired in MWM (21 days), CFC (1 day) |
[143] |
| Inositol 1,4,5-triphosphate 3-kinase KI | Enhanced CA1 LTP | No change in MWM | [144] |
KO, knockout; Tg, transgenic; KI, knock-in; MWM, Morris water maze; RAM, radial arm maze; ORT, object recognition test; CFC, contextual fear conditioning; PA, passive avoidance; *impaired in contextual discrimination test.