Table 1.

Summary of Features Compared among hPSC-Derived Perivascular Cells

Cell Type/Features	Con-vSMCs	Syn-vSMCs	Pericytes
Morphology	large, spindle-like	small, spindle-like	colony-like, flat, polygonal
Proliferation rate	+	+++	+
Cell size	+++	++	+
Endoplasmic reticulum	dilated	nondilated	dilated+ nondilated
Markers	SMA, calponin, NG2, PDGFRβ, SMMHC	SMA, calponin, NG2, PDGFRβ, SMMHClow	SMA, calponin NG2, PDGFRβ
ECM mRNA expression	collagen Ihigh, collagen IVhigh, fibronectin, laminin	collagen I, collagen IV, fibronectin, laminin	collagen I, collagen IV, fibronectinhigh, laminin
ECM deposition	collagen I, collagen IVfibrous, fibronectin, laminindiffuse, elastin	collagen Ilow, collagen IVglobular, fibronectin, laminindiffuse	collagen IVglobular, fibronectin, lamininpunctuate
MMPs	14 (MT-1)	2, 9	2, 14
Mesenchymal differentiation	—	—	adipogenic, osteogenic
In vivo integration	alignment, circumferential wrapping, tube narrowing	alignment	alignment, circumferential wrapping
Migration	−/+	+++	++
Invasion	−/+	+++	+
Contractility	+++	+	−/+

Note that values are relative to the three cell types examined.