Table 4.
ORs (95% CIs) of incident T2D by quartiles of urinary concentrations of BPA according to the menopausal status of cases: the NHS and NHSII.
| Menopausal status at diabetes diagnosis | Quartile 1 (lowest) | Quartile 2 | Quartile 3 | Quartile 4 (highest) | ptrend | pinteraction |
|---|---|---|---|---|---|---|
| Premenopause | ||||||
| Case/control (n) | 39/45 | 54/55 | 77/79 | 80/71 | ||
| Model 1a | 1.0 | 2.53 (0.82, 7.76) | 3.39 (1.14, 10.09) | 5.83 (1.68, 20.19) | 0.01 | 0.03 |
| Postmenopause | ||||||
| Case/control (n) | 194/197 | 191/188 | 162/162 | 174/172 | ||
| Model 1a | 1.0 | 0.85 (0.59, 1.23) | 0.85 (0.57, 1.27) | 0.83 (0.54, 1.27) | 0.50 | |
| aAdjusted for matching factors, BMI, smoking status, postmenopausal hormone use (NHS only), oral contraceptive use (NHSII only), physical activity, alcohol use, family history of diabetes, history of hypercholesterolemia or hypertension, urinary creatinine levels, and AHEI score. | ||||||