Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 14;122(6):559–565. doi: 10.1289/ehp.1307832

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.

PMC Copyright notice

As₂O₃ reduced osteoblast differentiation of BMSCs. BMSCs were isolated from bones of control rats and cultured in differentiation medium (DM) with 0, 0.5, or 1 μM As₂O₃ for 5–20 days. ALP activity on days 5 and 7 (A), calcium absorption on days 5 and 14 (B), and osteoblast mineralization on days 14 and 20 (C) during differentiation. Data are presented as mean ± SD of three independent experiments in triplicate. (D) mRNA expression of Bmp2 and osteocalcin (OCN) on days 5, 10, and 14 detected by real-time PCR. GAPDH was used as a control; results are representative of at least three independent experiments in triplicate. n = 3/group/day.

*p < 0.05, compared with the 0‑μM As₂O₃ + DM group.