Fig. 1.

Crystal structure of the TYK2 pseudokinase–kinase. (A) Simplified domain structure of TYK2 indicating the boundaries of the pseudokinase–kinase construct used in this study. (B) Diagram of the pseudokinase (blue) and kinase (tan) complex. From this view, the N and C termini of the crystallized construct are visible. Protein backbone is shown with the all-atom surface of the kinase domain displayed to aid consideration of the interaction interface. The kinase inhibitor molecule compound 7012 is shown in the active site as spheres (carbon atoms colored purple). (C) The diagram from B is rotated 180°, with pseudokinase and kinase represented in the same color, but the surface of the pseudokinase is shown. In this view, the region of the interdomain linker between the pseudokinase and kinase are visible, with a distance measurement and a dashed line shown to illustrate the connection made by the unobserved peptide linkage. Simplified diagrams are shown beneath each panel for orientation.