Fig. 2.

KI mice are hypertensive compared with WT littermates. In vivo telemetric blood pressure monitoring compared KI mice with WT littermate controls. (A and B) MAP over time as 12-h time-averaged results showed KI mice were hypertensive compared with WT controls. (C–G) Ang II treatment increased BP in both genotypes, but this response was potentiated compared with KI. NO₂-OA abrogated Ang II-induced hypertension in WT mice, but had no impact in KI mice. Data are shown as mean delta MAP ± SEM following NO₂-OA treatment.