Fig. 3.

EET/DHET ratio and HETE concentrations in plasma of WT and KI mice. (A) The 15-HETE and 11-HETE were significantly lower in the plasma of KI mice compared with WT, with 9-HETE and 8-HETE showing the same trend. (B) The plasma EET/DHET ratio increased in Ang II-induced hypertensive WT mice after NO₂-OA treatment but not in KI mice. (C) Hearts from WT mice treated with Ang II became hypertrophic, whereas KI mice displayed a slightly potentiated response. NO₂-OA attenuated Ang II-induced cardiac hypertrophy in WT mice and not in KI mice (*P < 0.05 ANOVA with post hoc t test).