Table 2.
Drug-Related Side Effects
| Bendamustine Dose Level in mg/m2 Twice Daily for 4 Days |
|||
|---|---|---|---|
|
Number With Toxicity
Grade 1/2 |
50 | 75 | 100 |
| Number Treated | 6 | 13 | 6 |
| Creatinine Elevation | 1/1 | 1/2 | 3/3 |
| Nausea and Vomiting | 3/1 | 2/2 | 2/1 |
| Diarrhea | 3/0 | 0/1 | 1/2 |
| Mucositis | 1/0 | 0/0 | 0/0 |
| Liver Function Abnormality | 1/0 | 2/1 | 1/0 |
| Other | 1 Headache grade 1 | 1 Rash grade 2 | — |
Two patients had Grade 3-4 liver function abnormalities at 75 mg/m2; these were attributed to events unrelated to bendamustine (combination of infections and medications).