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. 2014 Jun 10;6:107. doi: 10.3389/fnagi.2014.00107

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Copyright © 2014 Culley, Snayd, Baxter, Xie, Lee, Rudolph, Inouye, Marcantonio and Crosby.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipopolysaccharide selectively impaired attention/executive function in aged rats. Twenty-four-month-old Fischer-344 rats (N = 11) were tested on two simple discrimination (SD) tasks, one from each dimension (medium and shape) prior to receiving LPS 50 μg/kg or an equal volume of saline i.p. They were tested on the compound discrimination (CD) task and compound discrimination reversal (CD-R) on day 1 after LPS, the intradimensional shift (IDS) and intradimensional shift reversal (IDS-R) on day 2 after LPS, and the extradimensional shift (EDS) on day 3 after LPS. There were no differences between the groups at baseline. LPS did not affect performance on the CD or IDS task but impaired performance on the CD-R and the EDS. This indicates LPS had no effect on simple discrimination learning but did impair attention/executive function for at least 3 days. Data are mean ± SEM. *P ≤ 0.05, **P ≤ 0.01 by two-way ANOVA.