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Influence of BIBF1120 on the capacity of the TK domains of FGFR-A and FGFR-B to induce GVBD in Xenopus oocytes.
| BIBF1120 | 0μM | 0.5μM | 1μM | 2μM | 5μM | 10μM |
|---|---|---|---|---|---|---|
| FGFR-A_TK-wt | 100 | 100 | 100 | 82.5 | 0 | 0 |
| FGFR-B_TK-active | 100 | 100 | 70 | 0 | 0 | 0 |
FGFR-TK induced GVBD (numbers represent % GVBD; mean of two independent experiments) in Xenopus oocytes was completely blocked by BIBF1120 at concentrations of 2 and 5μM, respectively.
