Figure 2.

DAO enzyme histochemistry in human and mouse CNS. DAO activity was visualized using D-proline as a substrate in various regions of brain. Shown are (A–C) human cerebral cortex, (D) human hippocampus, (E) mouse forebrain including cerebral cortex and hippocampus (a coronal section), (F) posterior limb of human internal capsule (a horizontal section), (G) mouse striatum and internal capsule (a coronal section), (H) posterior lobe in human cerebellar hemisphere, (I) mouse cerebellar hemisphere, (J) human mesencephalon, (K) mouse mesencephalon, (L) basilar part of human pons, (M) mouse pons, (N) human medulla oblongata, (O) mouse medulla oblongata, (P) human thoracic spinal cord, and (Q) mouse thoracic spinal cord. (J–Q) Upper sides of the images are dorsal; bottom sides are ventral. (B,F,J,L,N,P) Arrows indicate the corticospinal tract. Each image of humans was low magnified to compare them to the corresponding image of mice, and the magnification percentage is different in each image.