Skip to main content
. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Nature. 2014 Feb 19;506(7489):451–455. doi: 10.1038/nature13109

Extended Data Figure 7. Analysis of C11orf95-RELA translocation and expression in formalin fixed paraffin embedded (FFPE) human and mouse ependymoma.

Extended Data Figure 7

(a) FFPE cohort (top) and results (middle) of break-apart FISH (bFISH) and rtPCR analysis of the C11orf95-RELA translocation and transcript, respectively. Tumors with ‘unavailable’ data had insufficient material for analysis. (b) GFAP, p-S276-RELA, CCND1 and L1CAM immunohistochemistry in human and mouse RELAFUS positive and negative cases. The mouse tumours recapitulate the ‘vascular-variant’ of human supratentorial ependymoma (see H&E). This subtype is characterized a branching network of capillaries (white arrows) and cytoplasmic clearing (black arrows). ***=p<0.0005. Scale bar=50μm