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. 2014 Jun;141(12):2452–2461. doi: 10.1242/dev.107797

Fig. 4.

Fig. 4.

Sensory neurons mediating differing sensory modalities poorly innervate target tissues in Wnt1-Cre+;Elp1f/f (Wnt1-cKO) mice. (A-C) Cutaneous innervation to the footpad identified by immunohistochemistry for peripherin (Prph), which primarily labels axons mediating pain and temperature sensation, and neurofilament-H (NF-H), which primarily labels axons mediating mechanosensation, were decreased by over 90% in Wnt1-cKO mice compared with Wnt1-Cre+;Elp1+/+ (Wnt1-Ctl) mice (Wnt1-Ctl normalized mean±s.e.m. total fluorescence intensity per unit area). In skeletal muscle, parvalbumin (Pv) labeled proprioceptive sensory innervation to muscle spindle stretch receptors was decreased by over 90% in Wnt1-cKO relative to Wnt1-Ctl mice (Wnt1-Ctl normalized mean±s.e.m. of Pv+ innervated stretch receptor profiles per section). Results are from three animals of each genotype; *P<0.001, Student's paired t-test. Scale bars: 70 μm.

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