. Author manuscript; available in PMC: 2014 Jul 23.

Published in final edited form as: Nature. 2013 Dec 11;505(7484):550–554. doi: 10.1038/nature12825

Extended Data Table 5.

PLD3 is associated with risk for AD in African-Americans

	Cases (n=130)		Controls (n=172)
Variant	carriers	Carrier Freq %	carriers	Carrier Freq %	p-value	OR (95% CI)
G63S	1	0.77%	0	0.00%	0.43	NA
K228R	1	0.77%	0	0.00%	0.43	NA
V232M	3	2.31%	0	0.00%	0.07	NA
I364I	6	4.62%	4	2.33%	0.33	2.02 (0.56-7.29)
A442A	4	3.08%	0	0.00%	0.03	NA

Total	15	11.54%	4	2.33%	1.4×10⁻⁰³	5.48 (1.77-16.92)

PLD3 was sequenced in a total of 302 African-Americans. Table shows the counts for single SNPs and the gene-based analysis for PLD3 in 130 AA cases and 172 controls. P-values were calculated using the Fisher's exact test.