Table 2.

Properties and localization of PAR degrading enzymes

Gene name	Alternative name	Cleave ribose–ribose bonds?	Cleave between ADP-ribose and acidic residues?	Localization
PARG		+	−	Cytoplasm, nucleus, mitochondria
ARH3	ADPRHL2	+	Not tested	Cytoplasm, nucleus, mitochondria
MacroD1	LRP16	−	+	Cytoplasm, nucleus
MacroD2	C20orf133	−	+	Cytoplasm, nucleus
TARG1	C6orf130, OARD1	−	+	Cytoplasm, nucleus

ARH3, ADP-ribosylhydrolase 3; PARG, poly(ADP-ribose) glycohydrolase; TARG1, terminal ADP-ribose protein glycohydrolase 1.