Figure 6.

Model of the role of BRCA1 in meiosis. (A) Model of BRCA1-dependent amplification of DDR signals along the entirety of the XY axes and BRCA1-dependent formation of X-PCH. (B) Model of two distinct DDR pathways in meiotic silencing and meiotic recombination. In the wild type (WT), BRCA1 promotes ATR recruitment and DDR signal amplification on unsynapsed XY axes and suppresses ATR signals on synapsed autosomes. A dotted line indicates a possible effect of DSBs in meiotic silencing. BRCA1 is not directly required for meiotic recombination. There is some degree of interplay between these two pathways.